Evidence for a threshold in experience-dependent long-term changes of kitten visual cortex.

@article{Greuel1987EvidenceFA,
  title={Evidence for a threshold in experience-dependent long-term changes of kitten visual cortex.},
  author={J. M. Greuel and Heiko J. Luhmann and Wolf Singer},
  journal={Brain research},
  year={1987},
  volume={431 1},
  pages={141-9}
}
In order to determine the role of unstructured and of spontaneous activity in the developmental plasticity of the visual cortex, we blocked in 7 kittens the retinal activity of one eye completely by intraocular injections of tetrodotoxin (TTX) while the other eye was left open. Littermates of these kittens were monocularly deprived by lid suture and served as controls. In 3 additional kittens one eye was inactivated with TTX and the other closed by lid suture to assess whether mere asymmetries… CONTINUE READING

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