Evidence for a susceptibility gene (SLEH1) on chromosome 11q14 for systemic lupus erythematosus (SLE) families with hemolytic anemia

@article{Kelly2002EvidenceFA,
  title={Evidence for a susceptibility gene (SLEH1) on chromosome 11q14 for systemic lupus erythematosus (SLE) families with hemolytic anemia},
  author={J. Kelly and K. Thompson and J. Kilpatrick and T. Lam and S. Nath and C. Gray-McGuire and J. Reid and B. Namjou and C. Aston and G. Bruner and R. H. Scofield and J. Harley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99},
  pages={11766 - 11771}
}
  • J. Kelly, K. Thompson, +9 authors J. Harley
  • Published 2002
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • Hemolytic anemia is a forme fruste of systemic lupus erythematosus (SLE), being observed months or even years before the onset of other clinical manifestations in some patients. We hypothesized that hemolytic anemia in those SLE-affected patients would identify a group of SLE pedigrees that share a high degree of genetic homogeneity. From 160 multiplex SLE pedigrees, we sought evidence for linkage in 35 (16 African-American, 17 European-American, and 2 Hispanic) who had at least one SLE… CONTINUE READING
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