Evidence for a stepwise program of extrathymic T cell development within the human tonsil.

@article{McClory2012EvidenceFA,
  title={Evidence for a stepwise program of extrathymic T cell development within the human tonsil.},
  author={Susan McClory and Tiffany Hughes and Aharon G. Freud and Edward L. Briercheck and Chelsea Martin and Anthony J. Trimboli and Jianhua Yu and Xiaoli Zhang and Gustavo Leone and Gerard J Nuovo and Michael A. Caligiuri},
  journal={The Journal of clinical investigation},
  year={2012},
  volume={122 4},
  pages={1403-15}
}
The development of a broad repertoire of T cells, which is essential for effective immune function, occurs in the thymus. Although some data suggest that T cell development can occur extrathymically, many researchers remain skeptical that extrathymic T cell development has an important role in generating the T cell repertoire in healthy individuals. However, it may be important in the setting of poor thymic function or congenital deficit and in the context of autoimmunity, cancer, or… CONTINUE READING

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