Evidence for a second type of fibril branch point in fibrin polymer networks, the trimolecular junction.

  title={Evidence for a second type of fibril branch point in fibrin polymer networks, the trimolecular junction.},
  author={Michael W. Mosesson and James P Diorio and Kevin R. Siebenlist and Joseph S. Wall and James F. Hainfeld},
  volume={82 5},
Fibrin molecules polymerize to double-stranded fibrils by intermolecular end-to-middle domain pairing of complementary polymerization sites, accompanied by fibril branching to form a clot network. Mass/length measurements on scanning transmission electron microscopic images of fibrils comprising branch points showed two types of junctions. Tetramolecular junctions occur when two fibrils converge, creating a third branch with twice the mass/length of its constituents. Newly recognized… CONTINUE READING

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