Evidence for a schizophrenia vulnerability locus on chromosome 8p in the Irish Study of High-Density Schizophrenia Families.

@article{Kendler1996EvidenceFA,
  title={Evidence for a schizophrenia vulnerability locus on chromosome 8p in the Irish Study of High-Density Schizophrenia Families.},
  author={Kenneth S. Kendler and Christopher James Maclean and Francis Anthony O'Neill and John Pius Burke and Brenda A. Murphy and Fiona Duke and Rosemarie Shinkwin and Stephen M. Easter and Bradley Todd Webb and Jing Zhang and Dermot P. J. Walsh and Richard E Straub},
  journal={The American journal of psychiatry},
  year={1996},
  volume={153 12},
  pages={
          1534-40
        }
}
OBJECTIVE This study was an attempt to replicate evidence for a vulnerability locus for schizophrenia and associated disorders in the 8p22-21 region reported by Pulver and colleagues. METHOD The linkage sample of the Irish Study of High-Density Schizophrenia Families consists of 265 multiplex families containing 1,408 individuals. Fifteen markers covering 30 centimorgans on chromosome 8p were tested. Three statistical methods were used: two-point and multipoint heterogeneity lod scores and a… CONTINUE READING
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