Evidence for a role of the lumenal M3-M4 loop in skeletal muscle Ca(2+) release channel (ryanodine receptor) activity and conductance.

@article{Gao2000EvidenceFA,
  title={Evidence for a role of the lumenal M3-M4 loop in skeletal muscle Ca(2+) release channel (ryanodine receptor) activity and conductance.},
  author={Lan Gao and David M. Balshaw and Le Xu and Ashutosh Tripathy and Cuiyan Xin and Gerhard Meissner},
  journal={Biophysical journal},
  year={2000},
  volume={79 2},
  pages={828-40}
}
We tested the hypothesis that part of the lumenal amino acid segment between the two most C-terminal membrane segments of the skeletal muscle ryanodine receptor (RyR1) is important for channel activity and conductance. Eleven mutants were generated and expressed in HEK293 cells focusing on amino acid residue I4897 homologous to the selectivity filter of K(+) channels and six other residues in the M3-M4 lumenal loop. Mutations of amino acids not absolutely conserved in RyRs and IP(3)Rs (D4903A… CONTINUE READING
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