Evidence for a role of the genomic region of the gene encoding for the alpha1 chain of type IX collagen (COL9A1) in hip osteoarthritis: A population-based study.

@article{Alizadeh2005EvidenceFA,
  title={Evidence for a role of the genomic region of the gene encoding for the alpha1 chain of type IX collagen (COL9A1) in hip osteoarthritis: A population-based study.},
  author={Behrooz Z. Alizadeh and Omer T. Njajou and Casper Bijkerk and Ingrid Meulenbelt and Signe Wildt and Albert Hofman and Huib A. P. Pols and Pieternella E Slagboom and Cornelia M. van Duijn},
  journal={Arthritis and rheumatism},
  year={2005},
  volume={52 5},
  pages={1437-42}
}
OBJECTIVE Type IX collagen proteoglycan is an important protein in collagen networks and has been implicated in hip osteoarthritis (OA). We studied 2 COL9A1 markers (509-8B2 and 509-12B1) in relation to radiographic OA, within the framework of the Rotterdam Study, a population-based study of 7,983 subjects ages 55 years and older. METHODS We used 2 different designs, as follows: 1) a linkage study of 83 probands with multiple joints affected with radiographic OA and their 221 siblings… CONTINUE READING
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