Evidence for a role of the cellular ND10 protein PML in mediating intrinsic immunity against human cytomegalovirus infections.

@article{Tavalai2006EvidenceFA,
  title={Evidence for a role of the cellular ND10 protein PML in mediating intrinsic immunity against human cytomegalovirus infections.},
  author={Nina Tavalai and Peer Papior and Sabine Rechter and Martina Leis and Thomas Stamminger},
  journal={Journal of virology},
  year={2006},
  volume={80 16},
  pages={
          8006-18
        }
}
Several viruses, including human cytomegalovirus (HCMV), encode proteins that colocalize with a cellular subnuclear structure known as ND10. Since only viral DNA deposited at ND10 initiates transcription, ND10 structures were hypothesized to be essential for viral replication. On the other hand, interferon treatment induces an up-regulation of ND10 structures and viruses have evolved polypeptides that disperse the dot-like accumulation of ND10 proteins, suggesting that ND10 could also be part… CONTINUE READING

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