Evidence for a role of p38 MAP kinase in expression of alkaline phosphatase during osteoblastic cell differentiation.

@article{Suzuki2002EvidenceFA,
  title={Evidence for a role of p38 MAP kinase in expression of alkaline phosphatase during osteoblastic cell differentiation.},
  author={Ayano Suzuki and J{\'e}r{\^o}me Guicheux and Gaby Palmer and Yoshihiro Miura and Yutaka Oiso and J. P. Bonjour and Joseph Caverzasio},
  journal={Bone},
  year={2002},
  volume={30 1},
  pages={
          91-8
        }
}
In the present study, we investigate the implication of the mitogen-activated protein kinases (MAPKs) Erk, p38, and JNK in mediating the effect of fetal calf serum (FCS) on the differentiation of MC3T3-E1 osteoblast-like cells. Erk is stimulated by FCS in proliferating, early-differentiating, as well as in mature cells. Activation of p38 by FCS is not detected in proliferating cells but is observed as the cells differentiate. JNK is activated in response to FCS throughout the entire… CONTINUE READING
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Heterotrimeric G proteins as fluoride targets in bone (review).

  • International journal of molecular medicine
  • 1999
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