Evidence for a role of mitogen-activated protein kinases in proliferating and differentiating odontogenic epithelia of inflammatory and developmental cysts.

@article{Nickolaychuk2002EvidenceFA,
  title={Evidence for a role of mitogen-activated protein kinases in proliferating and differentiating odontogenic epithelia of inflammatory and developmental cysts.},
  author={Brent Nickolaychuk and A Mcnicol and James Gilchrist and Catalena Birek},
  journal={Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics},
  year={2002},
  volume={93 6},
  pages={720-9}
}
OBJECTIVE The activation of intracellular signaling cascades involving serine/threonine kinases ERK1/2 has been variably reported either to stimulate or inhibit epithelial cell differentiation in response to extracellular signals. The purpose of our study was to determine the distribution of the signaling molecule ERK1 and its activated form pERK1/2 in the epithelial components of developmental and inflammatory odontogenic cysts in relation to parameters of differentiation and proliferation… CONTINUE READING