Evidence for a role of ganglioside GM1 in antigen presentation: binding enhances presentation of Escherichia coli enterotoxin B subunit (EtxB) to CD4(+) T cells.

@article{Nashar2001EvidenceFA,
  title={Evidence for a role of ganglioside GM1 in antigen presentation: binding enhances presentation of Escherichia coli enterotoxin B subunit (EtxB) to CD4(+) T cells.},
  author={Toufic O Nashar and Zoe E. Betteridge and Richard J. Mitchell},
  journal={International immunology},
  year={2001},
  volume={13 4},
  pages={541-51}
}
Successful antigen presentation by antigen-presenting cells is governed by a number of factors including the efficiency of antigen capture by cell-surface receptors, targeting to compartments of antigen processing, surface expression of MHC II-peptide complexes and presence of co-stimulatory signals. Ganglioside GM1 is an important component of membrane glycosphingolipids, and has been implicated in cell differentiation, apoptosis and signal transduction pathways. Using the B subunit of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 34 references

High levels of major histocompatibility complex II

  • R M.
  • 1997
Highly Influential
3 Excerpts

Fcγ receptor-mediated 25 Matousek, M

  • P. Castagnoli, S. Amigorena
  • P., Nedrud, J. G. and Harding, C. V. 1996…
  • 1999

Involvement of MIIC-like late endosomes in B Capping of cholera toxin-ganglioside GM1 complexes on mouse

  • P. Webster
  • 1999

andheterologous expression and secretion in a marine vibrio

  • A. M. Shenoy-Scaria, D. J. Dietzen, J. Kwong, D. C. Link
  • 1999

lipid rafts accompanies signalling via the T cell antigen receptor

  • E. A. Merritt, S. Sarfaty, M. G. Jobling, T. Chang, R. Holmes
  • 1999

Dendritic cells and cholera toxin induces B cell surface DR expression while it inhibits

  • J. Banchereau, R. M. Steinman
  • 1998

Similar Papers

Loading similar papers…