Evidence for a role of epithelial mesenchymal transition during pathogenesis of fistulae in Crohn's disease.

@article{Bataille2008EvidenceFA,
  title={Evidence for a role of epithelial mesenchymal transition during pathogenesis of fistulae in Crohn's disease.},
  author={Frauke Bataille and Christian Rohrmeier and Richard J. S. Bates and Achim Weber and F Rieder and Julia Brenmoehl and Ulrike Strauch and Stefan Farkas and Alois Fuerst and Ferdinand Hofstaedter and Juergen Schoelmerich and Hans Herfarth and Gerhard Rogler},
  journal={Inflammatory bowel diseases},
  year={2008},
  volume={14 11},
  pages={
          1514-27
        }
}
BACKGROUND The pathogenesis of fistulae in Crohn's disease (CD) patients is barely understood. We recently showed that more than two-thirds of CD fistulae are covered with flat, mesenchymal-like cells (transitional cells [TC]) forming a patchy basement membrane. Epithelial-to-mesenchymal transition (EMT) is a process of reprogramming epithelial cells, allowing them to migrate more effectively and giving epithelial cells an "invasive" potential. EMT has been suggested to be crucial in fibrosis… CONTINUE READING

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