Evidence for a role of chloroethylaziridine in the cytotoxicity of cyclophosphamide

Abstract

A number of investigators have observed that the use of 4-hydroperoxycyclophosphamide (4-HC) in multiwell plate cytotoxicity assays can be associated with toxicity to cells in wells that contain no drug. Previous reports have implicated diffusion of 4-HC decomposition products, and acrolein in particular, as the active species. Purpose: The purpose of this… (More)
DOI: 10.1007/s002800050049

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