Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling.

@article{Atfi1997EvidenceFA,
  title={Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling.},
  author={Azeddine Atfi and Siham Djelloul and Eric Chastre and Richard 1. Davis and Christian P Gespach},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 3},
  pages={1429-32}
}
Transforming growth factor beta (TGF-beta) is a multifunctional factor that induces a wide variety of cellular processes which affect growth and differentiation. TGF-beta exerts its effects through a heteromeric complex between two transmembrane serine/threonine kinase receptors, the type I and type II receptors. However, the intracellular signaling pathways through which TGF-beta receptors act to generate cellular responses remain largely undefined. Here, we report that TGF-beta initiates a… CONTINUE READING