Evidence for a role of NisT in transport of the lantibiotic nisin produced by Lactococcus lactis N8.

@article{Qiao1996EvidenceFA,
  title={Evidence for a role of NisT in transport of the lantibiotic nisin produced by Lactococcus lactis N8.},
  author={M. Qiao and Per Erik Joakim Saris},
  journal={FEMS microbiology letters},
  year={1996},
  volume={144 1},
  pages={
          89-93
        }
}
The biosynthesis, immunity and regulation of nisin, a lanthionine-containing antimicrobial peptide produced by Lactococcus lactis, is encoded by two gene clusters, nisA/ZBTCIPRK and nisFEG. The mutant strain LAC46 with a deletion in the translocator gene nisT could not secrete nisin but nisin activity was detected from cell lysates. The nisT mutation was complemented by a NisT-expression plasmid resulting in restored capacity to secrete nisin. These results demonstrate that NisT is the… CONTINUE READING

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