Evidence for a role of Nav1.6 in facilitating increases in neuronal hyperexcitability during epileptogenesis.

@article{Hargus2013EvidenceFA,
  title={Evidence for a role of Nav1.6 in facilitating increases in neuronal hyperexcitability during epileptogenesis.},
  author={Nicholas James Hargus and Aradhya Nigam and Edward H. Bertram and Manoj K Patel},
  journal={Journal of neurophysiology},
  year={2013},
  volume={110 5},
  pages={1144-57}
}
During epileptogenesis a series of molecular and cellular events occur, culminating in an increase in neuronal excitability, leading to seizure initiation. The entorhinal cortex has been implicated in the generation of epileptic seizures in both humans and animal models of temporal lobe epilepsy. This hyperexcitability is due, in part, to proexcitatory changes in ion channel activity. Sodium channels play an important role in controlling neuronal excitability, and alterations in their activity… CONTINUE READING