Evidence for a role of D1 dopamine receptors in d-amphetamine’s effect on timing behaviour in the free-operant psychophysical procedure

@article{Cheung2006EvidenceFA,
  title={Evidence for a role of D1 dopamine receptors in d-amphetamine’s effect on timing behaviour in the free-operant psychophysical procedure},
  author={Timothy H. C. Cheung and G. Bezzina and Karim Asgari and Simon C. Body and Kevin C.F. Fone and Christopher M. Bradshaw and Elem{\'e}r Szabadi},
  journal={Psychopharmacology},
  year={2006},
  volume={185},
  pages={378-388}
}
RationaleTemporal differentiation of operant behaviour is sensitive to dopaminergic manipulations. Studies using the fixed-interval peak procedure implicated D2 dopamine receptors in these effects. Less is known about the effects of dopaminergic manipulations on temporal differentiation in other timing schedules.ObjectiveTo examine the effects of a D1 antagonist,8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol (SKF-83566), and a D2 antagonist, haloperidol, on performance on the… 

Figures and Tables from this paper

Evidence for the sensitivity of operant timing behaviour to stimulation of D1 dopamine receptors
TLDR
Stimulation of D1-like dopamine receptors affects performance on the free-operant psychophysical procedure and the interaction between SKF-81297 and a D2-like receptor antagonist haloperidol, were examined.
Attenuation of the effects of d-amphetamine on interval timing behavior by central 5-hydroxytryptamine depletion
TLDR
d-Amphetamine’s effect on performance in the free-operant psychophysical procedure requires an intact 5-HTergic system, and5-HT, possibly acting at 5- HT2A receptors, may play a ‘permissive’ role in dopamine release.
Effect of quinpirole on timing behaviour in the free-operant psychophysical procedure: evidence for the involvement of D2 dopamine receptors
TLDR
Results suggest that quinpirole reduced T50 via an action at D2 receptors, suggesting that D1-like and D2-like receptors may mediate behaviourally similar but pharmacologically distinct effects on timing behaviour.
Dopamine receptor antagonists reverse amphetamine-induced behavioral alteration on a differential reinforcement for low-rate (DRL) operant task in the rat.
TLDR
The co-administration of amphetamine with SCH23390 or raclopride reversed the aforementioned amphetamine-induced behavioral deficiency on DRL task, suggesting that the dopamine D1 and D2 receptors are involved and important to the temporal regulation of DRL response under psychostimulant drug treatment.
Effects of d-amphetamine and DOI (2,5-dimethoxy-4-iodoamphetamine) on timing behavior: interaction between D1 and 5-HT2A receptors
TLDR
The results suggest that both 5-HT2A and D1 receptors, but not D2 receptors, are involved in d-amphetamine’s effect on timing behavior in the free-operant psychophysical procedure.
Tolerance to the effect of 2,5-dimethoxy-4-iodoamphetamine (DOI) on free-operant timing behaviour: interaction between behavioural and pharmacological mechanisms
TLDR
The finding of cross-tolerance to d- methamphetamine but not to quinpirole suggests that the reduction of T50 in the free-operant psychophysical procedure may be brought about by two distinct pharmacological mechanisms, one activated by DOI and d-amphetamine, and the other by quin pirole.
Effects of SKF-83566 and haloperidol on performance on progressive ratio schedules maintained by sucrose and corn oil reinforcement: quantitative analysis using a new model derived from the Mathematical Principles of Reinforcement (MPR)
TLDR
The results are consistent with the hypothesis that blockade of both D1-like and D2-like receptors reduces the incentivevalue of sucrose, whereas the incentive value of corn oil is more sensitive to blockade of D2 -like than D1 -like receptors.
New Findings on the Sensitivity of Free-Operant Timing Behaviour to 5-Hydroxytryptamine Receptor Stimulation
TLDR
The results suggest that mCPP’s effect on timing is mediated by an agonistic action at 5-HT1A and 4-HT2A, but not 5- HT1B, receptors, while Ro-600175 had no effect on T50.
Role of dopaminergic DAD1 and DAD2 receptors in the sensitization of amphetamine-suppressed schedule-induced polydipsia in rats.
TLDR
SIP could be a useful paradigm to study AMPH sensitization in rats and the involvement of dopamine receptors might be different, but pretreatment with DAD2 antagonist haloperidol (HAL) prevented the sensitization to AMPH in the long-term rather than short-term withdrawal conditions.
...
1
2
3
...

References

SHOWING 1-10 OF 64 REFERENCES
Effects of fenfluramine on free-operant timing behaviour: evidence for involvement of 5-HT2A receptors
TLDR
The results suggest that fenfluramine affects temporal differentiation via the release of endogenous 5-HT which acts mainly on postsynaptic 5- HT2A receptors.
The effect of d-amphetamine on performance on two operant timing schedules
TLDR
The results of experiment 2 support the notion that different neural mechanisms may be involved in timing tasks involving temporal distribution of responding and discrimination of the duration of exteroceptive stimuli and support the proposal that the drug reduces the period of the hypothetical pacemaker.
Effects of selective dopamine D1- and D2-agonists and antagonists on timing performance in rats
Effects of a 5-HT2 receptor agonist, DOI (2,5-dimethoxy-4-iodoamphetamine), and antagonist, ketanserin, on the performance of rats on a free-operant timing schedule
TLDR
The results show that DOI alters temporal differentiation in the free-operant psychophysical procedure, and the antagonistic effect of ketanserin indicates that the effect of DOI was probably mediated by 5-HT2A rather than 5- HT2C receptors, since ketanserserin is relatively selective for 5-ht2A receptors.
Effect of central 5-hydroxytryptamine depletion on performance in the free-operant psychophysical procedure: facilitation of switching, but no effect on temporal differentiation of responding
TLDR
The results provide further evidence for the involvement of the ascending 5- HTergic pathways in switching between response alternatives, but cast doubt on the previous suggestion that the effects of 5-HT depletion on temporal differentiation of behaviour are mediated by facilitated switching.
Effect of destruction of the 5-hydroxytryptaminergic pathways on behavioural timing and “switching” in a free-operant psychophysical procedure
TLDR
The results confirm previous findings that behaviour in timing schedules is sensitive to destruction of the central 5HTergic pathways, and suggest that these pathways may contribute to the inhibitory regulation of switching between behavioural states.
Locomotor behaviors in response to new selective D-1 and D-2 dopamine receptor agonists, and the influence of selective antagonists
Effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on performance on two operant timing schedules
TLDR
The results support the notion that different neural mechanisms may be involved in timing tasks involving temporal distribution of responding and discrimination of the durations of exteroceptive stimuli, and support the proposal that 5-HTergic mechanisms help to regulate the period of the hypothetical pacemaker.
A role for presynaptic mechanisms in the actions of nomifensine and haloperidol
Acute administration of haloperidol enhances dopaminergic transmission.
  • T. Lidsky, S. Banerjee
  • Psychology, Biology
    The Journal of pharmacology and experimental therapeutics
  • 1993
TLDR
It is suggested that acute administration of haloperidol actually augments dopaminergic activity due to relatively strong presynaptic actions and relatively weak postsynaptic blocking effects, and it is plausible that this initial increase in dopamine transmission may participate in producing the neural changes evoked by chronic haloperIDol administration that allow this drug to have antipsychotic potency.
...
1
2
3
4
5
...