Evidence for a role for the Dictyostelium Rap1 in cell viability and the response to osmotic stress.

@article{Kang2002EvidenceFA,
  title={Evidence for a role for the Dictyostelium Rap1 in cell viability and the response to osmotic stress.},
  author={Rujun Kang and Helmut Kae and Hermia Ip and George B. Spiegelman and Gerald R. Weeks},
  journal={Journal of cell science},
  year={2002},
  volume={115 Pt 18},
  pages={3675-82}
}
The Dictyostelium genome contains a single rapA gene, which encodes a Rap1 monomeric G protein. As attempts at generating rapA-null Dictyostelium cells had been unsuccessful, expression of antisense RNA from the rapA gene under control of the folate repressible discoidin promoter was used to reduce cellular levels of the Rap1 protein. As Rap1 levels gradually decreased following antisense rapA RNA induction, growth rate and cell viability also decreased, a result consistent with the idea that… CONTINUE READING
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