Evidence for a role for phospholipase C, but not phospholipase A2, in platelet activation in response to low concentrations of collagen.

@article{Lockhart2001EvidenceFA,
  title={Evidence for a role for phospholipase C, but not phospholipase A2, in platelet activation in response to low concentrations of collagen.},
  author={Leslie K. Lockhart and Caroline Pampolina and Brent Nickolaychuk and A Mcnicol},
  journal={Thrombosis and haemostasis},
  year={2001},
  volume={85 5},
  pages={882-9}
}
The release of arachidonic acid is a key component in platelet activation in response to low concentrations (1-20 microg/ml) of collagen. The precise mechanism remains elusive although a variety of pathways have been implicated. In the present study the effects of inhibitors of several potentially key enzymes in these pathways have been examined. Collagen 1-10 microg/ml) caused maximal platelet aggregation which was accompanied by the release of arachidonic acid, the synthesis of thromboxane A2… CONTINUE READING
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