Evidence for a role for bulbospinal pathways in the spinal antinociceptive effect of systemically administered vapreotide in normal rats

  title={Evidence for a role for bulbospinal pathways in the spinal antinociceptive effect of systemically administered vapreotide in normal rats},
  author={V Berger and Abdelkrim Alloui and Jean Louis K{\'e}m{\'e}ny and Claude Dubray and Alain Eschalier and Jeannine Lavarenne},
  journal={Fundamental \& Clinical Pharmacology},
Summary— Numerous neurotransmitters are involved in nociceptive transmission or regulation. Several reports have shown the analgesic effects of somatostatin and its analogues. Somatostatin, when given intrathecally, markedly reduced pain in cancer patients. Somatostatin analogues that possess a longer half‐life time are more convenient for therapeutic use. Vapreotide, a somatostatin analogue, was shown to induce a long‐lasting antinociceptive effect in rats. We studied the site and the… Expand
The epidural and intrathecal administration of somatotrophin-release inhibiting factor: Native and synthetic analogues
In this article, the literature on the natural drug and its synthetic analogue are reviewed, paying particular attention to the problems connected with intraspinal administration and analgesic properties. Expand
Effect of sec-O-glucosylhamaudol on mechanical allodynia in a rat model of postoperative pain
Intrathecal SOG showed a significant antinociceptive effect on the postoperative pain model and reverted by naloxone, and the effects of SOG seem to involve the MOR. Expand
Emerging analgesics in cancer pain management
Conotoxins and other drugs such as nicotinic acetylcholinergic receptor agonists will be advantageous only for a few patients in the near future, as side-effect profile and risk of complications, as well as the burden on the patient, often are not worth the additional analgesic benefit. Expand


Evidence for a central long-lasting antinociceptive effect of vapreotide, an analog of somatostatin, involving an opioidergic mechanism.
The antinociceptive effect of the octapeptide vapreotide was studied after systemic injection in normal mice using the hot plate and abdominal stretching assays, and in normal rats using the paw pressure analgesiometric assay. Expand
Supraspinal and spinal monoamine-modified function and the expression of opioid antinociception
  • R. Sewell
  • Psychology, Medicine
  • Journal of psychopharmacology
  • 1991
This topic is discussed using 5-hydroxytryptamine (5-HT) and noradrenaline (NA) systems, their locations and receptor sub-types, as prime candidates for modulating nociceptive and antinociception processes. Expand
Paracetamol exerts a spinal antinociceptive effect involving an indirect interaction with 5-hydroxytryptamine3 receptors: in vivo and in vitro evidence.
It is concluded that paracetamol has a central antinociceptive effect, based on an indirect involvement of spinal 5-HT3 receptors. Expand
Antinociceptive Interactions Between Alphha2‐Adrenergic and Opiate Agonists at the Spinal Level in Rodents
It appears that α2 adrenoceptor-mediated antinociception is independent of opiates receptor mechanisms, and clinical use of intrathecal combinations of α2,adrenergic and opiate receptor agonists to increase analgesia and use of intrusion-based α2 agonists for pain relief in patients tolerant to opiates might deserve evaluation. Expand
Differential influence of two serotonin 5-HT3 receptor antagonists on spinal serotonin-induced analgesia in rats
Evidence is provided that contrary to tropisetron, doses of granisetrons able to inhibit the effect of a 5-HT3 receptor agonist failed to reduce that of5-HT, demonstrating a heterogeneity between 5-ht3 receptor antagonists and questions the true involvement of these receptors in spinal 5- HT-induced antinociception. Expand
In vitro and in vivo evidence for a tachykinin NK1 receptor antagonist effect of vapreotide, an analgesic cyclic analog of somatostatin.
It is concluded that vapreotide possesses an antagonist activity on guinea-pig tachykinin NK1 receptors; the involvement in its analgesic action is discussed. Expand
Antinociceptive and ‘neurotoxic’ actions of somatostatin in rat spinal cord after intrathecal administration
It was found that the peptide caused antinociception, hind limb paralysis and neuronal damage of the spinal cord in a dose‐dependent manner after intrathecal injection of somatostatin. Expand
Involvement of bulbospinal pathways in the antinociceptive effect of clomipramine in the rat
The results showed that this effect was suppressed only in the hindpaw ipsilateral to the dorsolateral funiculus lesion, and suggest that the antinociceptive effect of antidepressants needs intact descending inhibitory bulbospinal pathways. Expand
Opiate-like naloxone-reversible actions of somatostatin given intracerebrally.
The blockade of SRIF action by naloxone pretreatment, along with binding ofSRIF to opiate receptor in vitro, suggest opiate receptors to be involved in the mediation of analgesia observed in present study. Expand
Towards the use of noradrenergic agonists for the treatment of pain : proceedings of the International Symposium on Towards the use of Noradrenergic Agonists for the Treatment of Pain, held in Versailles, France, 20-21 March 1992
Ascending pain pathways with special reference to the spino(trigemino)-ponto- amygdaloid tract (J.F. Bernard and J.M. Besson). The segmental control of pain (A.H. Dickenson and L.C. Stanf).Expand