Evidence for a regulatory role for histamine in gastric enterochromaffin-like cell proliferation induced by hypergastrinemia.

@article{Modlin1996EvidenceFA,
  title={Evidence for a regulatory role for histamine in gastric enterochromaffin-like cell proliferation induced by hypergastrinemia.},
  author={I. Modlin and Z. Zhu and L. Tang and M. Kidd and G. Lawton and K. Miu and R. Powers and J. Goldenring and D. Pasikhov and C. Soroka},
  journal={Digestion},
  year={1996},
  volume={57 5},
  pages={
          310-21
        }
}
  • I. Modlin, Z. Zhu, +7 authors C. Soroka
  • Published 1996
  • Biology, Medicine
  • Digestion
  • BACKGROUND/AIMS Hypergastrinemia, induced by sustained suppression of gastric acid secretion, is associated with gastric enterochromaffin-like (ECL) cell hyperplasia and carcinoid tumor formation. We examined the effect of a selective H1-histamine antagonist, terfenadine, on gastric mucosal cell proliferation to determine whether histamine might modulate ECL cell generation. METHODS The rodent mastomys received the H2-antagonist loxtidine (2 g/l drinking water) alone or in combination with… CONTINUE READING
    19 Citations
    The CCK2 receptor antagonist, YF476, inhibits Mastomys ECL cell hyperplasia and gastric carcinoid tumor development
    • 40
    Physiological significance of ECL-cell histamine.
    • 31
    Altered gastric chief cell lineage differentiation in histamine-deficient mice.
    • 26
    • PDF
    Role of CCN2/CTGF in the proliferation of Mastomys enterochromaffin-like cells and gastric carcinoid development.
    • 35
    • PDF
    Lack of histamine alters gastric mucosal morphology: comparison of histidine decarboxylase-deficient and mast cell-deficient mice.
    • 23
    • PDF