Evidence for a rapid, direct effect on epithelial monolayer integrity and transepithelial transport in response to Salmonella invasion

@article{Jepson1996EvidenceFA,
  title={Evidence for a rapid, direct effect on epithelial monolayer integrity and transepithelial transport in response to Salmonella invasion},
  author={Mark A. Jepson and Thomas F Lang and Karin A Reed and Nicholas L. Simmons},
  journal={Pfl{\"u}gers Archiv},
  year={1996},
  volume={432},
  pages={225-233}
}
In cultured monolayers of high-resistance Ma-din-Darby Canine Kidney (MDCK) cells, infection with Salmonella typhimurium SL1344 resulted in a dose- and time-dependent increase in transepithelial conductance (Gt) and short-circuit current (I sc). There was a direct linear relationship between the S. typhimurium- induced increments in I sc and Gt suggesting that this early change in epithelial parameters is, in part, the result of a cellular conductance change most probably at the apical membrane… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 30 references

Renal epithelial CI secretion

NL Simmons
Exp Pbysiol • 1993
View 7 Excerpts
Highly Influenced

Other bacterial diarrhoeas

Bailliere's clinical gastroenterology • 1993
View 3 Excerpts
Highly Influenced

Involvement of the epidermal growth factor receptor in the invasion of cultured mammalian cells by Salmonella typhimurium

JE Galfin, J Pace, MJ Hayman
Nature • 1992
View 5 Excerpts
Highly Influenced

Salmonella interactions with polarized human intestinal Caco-2 epithelial cells.

The Journal of infectious diseases • 1990
View 5 Excerpts
Highly Influenced