Evidence for a quinone binding site close to the interface between NUOD and NUOB subunits of Complex I.

@article{Prieur2001EvidenceFA,
  title={Evidence for a quinone binding site close to the interface between NUOD and NUOB subunits of Complex I.},
  author={I Prieur and Jo{\"e}l Lunardi and Alain Dupuis},
  journal={Biochimica et biophysica acta},
  year={2001},
  volume={1504 2-3},
  pages={173-8}
}
Piericidin, rotenone and pyridaben are specific inhibitors of the NADH-ubiquinone oxidoreductase (Complex I) that bind to its ubiquinone binding site(s). Using site directed mutagenesis, we demonstrate that residues G409, D412, R413 and V407 of the C-terminus of Complex I NUOD subunit are directly involved in the binding of these inhibitors. We propose that the corresponding inhibitor/quinone binding site would be located close to NUOD-NUOB interface. 

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