Evidence for a putative telomerase repressor gene in the 3p14.2-p21.1 region.

@article{Tanaka1998EvidenceFA,
  title={Evidence for a putative telomerase repressor gene in the 3p14.2-p21.1 region.},
  author={Hiromi Tanaka and Motoyuki Shimizu and Izumi Horikawa and Hiroyuki Kugoh and Jun Yokota and Jeffrey C. Barrett and Mitsuo Oshimura},
  journal={Genes, chromosomes & cancer},
  year={1998},
  volume={23 2},
  pages={123-33}
}
Telomeres, which are the repeated sequences located on both ends of chromosomes in eukaryotes, are known to shorten with each cell division, and their eventual loss is thought to result in cellular senescence. Unlike normal somatic cells, most tumor cells show activation of telomerase, a ribonucleoprotein enzyme that stably maintains telomere length by addition of the sequences of TTAGGG repeats to telomeres. The KC12 cell line derived from a renal cell carcinoma in a patient with von Hippel… CONTINUE READING