Evidence for a protective role of tumor necrosis factor in the acute phase of Trypanosoma cruzi infection in mice.

@article{Lima1997EvidenceFA,
  title={Evidence for a protective role of tumor necrosis factor in the acute phase of Trypanosoma cruzi infection in mice.},
  author={Elaine Alves Correia Lima and Irene Garcia and M H Vicentelli and Pierre Vassalli and Paola Marcella Camargo Minoprio},
  journal={Infection and immunity},
  year={1997},
  volume={65 2},
  pages={457-65}
}
A possible role for tumor necrosis factor (TNF) alpha during Trypanosoma cruzi infection was explored by using transgenic mice expressing in blood high levels of a soluble TNFR1-FcIgG3 fusion protein, which neutralizes the effects of TNF in vivo. Nontransgenic littermates were used as controls. The transgenic mice showed high susceptibility to T. cruzi… CONTINUE READING