Evidence for a protective role of interferon in resistance to murine cytomegalovirus and its control by non-H-2-linked genes.

@article{Grundy1982EvidenceFA,
  title={Evidence for a protective role of interferon in resistance to murine cytomegalovirus and its control by non-H-2-linked genes.},
  author={Jane E. Grundy and Jan Trapman and Jane E. Allan and Geoffrey R. Shellam and Cornelis J. M. Melief},
  journal={Infection and immunity},
  year={1982},
  volume={37 1},
  pages={143-50}
}
Murine cytomegalovirus (MCMV) induces rapid production of a partially pH 2-stable type 1 interferon, the serum level of which is controlled by non-H-2-linked host genes. The production of high, intermediate, and low levels of interferon was found in C3H/He, C57BL/10, and BALB/c mice, respectively, and the use of H-2 congenic mice on the BALB/c or C57BL/10 background showed that H-2-associated genes were not involved. Administration of large (up to 200,000 U) daily doses of partially purified… CONTINUE READING