Evidence for a positive role of SHIP in the BCR-ABL-mediated transformation of primitive murine hematopoietic cells and in human chronic myeloid leukemia.

@article{Jiang2003EvidenceFA,
  title={Evidence for a positive role of SHIP in the BCR-ABL-mediated transformation of primitive murine hematopoietic cells and in human chronic myeloid leukemia.},
  author={Xiaoyan Jiang and Matthew Stuible and Yves Chalandon and Andra Li and Wing Yiu Chan and Wolfgang Eisterer and Gerald Krystal and A. H. C. Eaves and Connie J. Eaves},
  journal={Blood},
  year={2003},
  volume={102 8},
  pages={2976-84}
}
Previous studies suggested that the SH2-containing inositol-5-phosphatase (SHIP) may play a tumor suppressor-like function in BCR-ABL-mediated leukemogenesis. To investigate this possibility, we first developed a new assay for quantitating transplantable multilineage leukemia-initiating cells (L-ICs) in hematopoietic stem cell (HSC)-enriched mouse bone marrow (BM) cells transduced with a BCR-ABL-GFP (green fluorescent protein) retrovirus. The frequency of L-ICs (1 of 430 Sca-1+lin- cells) was 7… CONTINUE READING