Evidence for a polyclonal nature of the cell infiltrate in sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease).

@article{Paulli1995EvidenceFA,
  title={Evidence for a polyclonal nature of the cell infiltrate in sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease).},
  author={Marco Paulli and Giovanni Bergamaschi and Loris Tonon and Alessandra Viglio and Rosario Rosso and Floriana Facchetti and Mireille Geerts and Umberto Magrini and Mario Cazzola},
  journal={British journal of haematology},
  year={1995},
  volume={91 2},
  pages={415-8}
}
Sinus histiocytosis with massive lymphadenopathy (SHML), or Rosai-Dorfman disease, is rare histiocytic disorder of known origin which shares several cell markers with Langerhans' cell histiocytosis (LCH). Although Rosai-Dorfman cells exhibit an aberrant immunophenotype, the indolent clinical course of SHML suggests a reactive disorder rather than a neoplastic process. Until recently this was prevailing opinion concerning LCH also, but recent studies have detected clonal histiocytes in all forms… CONTINUE READING
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