Evidence for a plasma-accessible carbonic anhydrase in the lumen of salmon heart that may enhance oxygen delivery to the myocardium

@article{Alderman2016EvidenceFA,
  title={Evidence for a plasma-accessible carbonic anhydrase in the lumen of salmon heart that may enhance oxygen delivery to the myocardium},
  author={Sarah L. Alderman and Till S. Harter and Jonathan M. Wilson and Claudiu T. Supuran and Anthony P. Farrell and Colin J Brauner},
  journal={Journal of Experimental Biology},
  year={2016},
  volume={219},
  pages={719 - 724}
}
ABSTRACT Oxygen supply to the heart of most teleosts, including salmonids, relies in part or in whole on oxygen-depleted venous blood. Given that plasma-accessible carbonic anhydrase (CA) in red muscle of rainbow trout has recently been shown to facilitate oxygen unloading from arterial blood under certain physiological conditions, we tested the hypothesis that plasma-accessible CA is present in the lumen of coho salmon (Oncorhynchus kisutch) hearts, and may therefore assist in the luminal… Expand
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  • Medicine, Chemistry
  • Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
  • 2020
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Teleost fishes have evolved a mechanism by which adrenergic sodium-proton-exchangers on the red blood cell membrane actively create H+ gradients that are short-circuited in the presence of plasma-accessible carbonic anhydrase at the tissue capillaries, which allows teleosts to unload more O2 at their tissues without compromising O2 diffusion gradients and therefore, to use the available O2 carrying capacity of the blood to a greater degree. Expand
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