Evidence for a pituitary site of gonadal steroid stimulation of GnRH receptors in female mice.

@article{Naik1985EvidenceFA,
  title={Evidence for a pituitary site of gonadal steroid stimulation of GnRH receptors in female mice.},
  author={S. I. Naik and Leonie S. Young and Harry M. Charlton and Richard N. Clayton},
  journal={Journal of reproduction and fertility},
  year={1985},
  volume={74 2},
  pages={
          615-24
        }
}
Treatment of GnRH-deficient (hpg) female mice with oestradiol-17 beta (E2) for 7 days increased GnRH receptors from 4.1 +/- 0.4 fmol/pituitary (control) to 7.2 +/- 0.7 fmol/pituitary (GnRH-treated), and consistently increased pituitary FSH content. Treatment of hpg female mice with E2 plus progesterone (P) for 14 days stimulated GnRH receptors more than did E2 alone, although values still remained lower than those of normal intact female mice. In contrast, GnRH treatment of intact hpg female… CONTINUE READING

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