Evidence for a peroxide-initiated free radical mechanism of prostaglandin biosynthesis.

@article{Hemler1980EvidenceFA,
  title={Evidence for a peroxide-initiated free radical mechanism of prostaglandin biosynthesis.},
  author={Martin E. Hemler and William E. M. Lands},
  journal={The Journal of biological chemistry},
  year={1980},
  volume={255 13},
  pages={6253-61}
}
High levels of NaCN (20 to 250 mM) were required to inhibit cyclooxygenase catalysis and cause extended lag periods (up to 1.6 min), whereas CO failed to inhibit catalysis. This NaCN inhibition was easily overcome by endogenous or exogenous hydroperoxides. Added hydroperoxides acted to eliminate lag periods without undergoing net conversion to other chemical species. In addition, experiments with glutathione peroxidase inhibition showed that hydroperoxides were essential not only in the early… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

References

Publications referenced by this paper.

Blochem

  • H. W. Cook, W. E. M. Lands
  • Biophys . Res . zglandin Biosy thesis
  • 1975

Similar Papers

Loading similar papers…