Evidence for a peripheral origin of the tonic nociceptive response to subcutaneous formalin

@article{Dallel1995EvidenceFA,
  title={Evidence for a peripheral origin of the tonic nociceptive response to subcutaneous formalin},
  author={Radhouane Dallel and Patrick Raboisson and Pierre Clavelou and Marwan Saade and Alain Woda},
  journal={Pain},
  year={1995},
  volume={61},
  pages={11-16}
}
The orofacial formalin test in the rat is a valid and reliable model of nociception and is sensitive to various classes of analgesic drugs. The noxious stimulus consists in an injection of diluted formalin (2.5% in saline) into the upper lip. The behavioural nociceptive response is measured in terms of the amount of time the animal spends rubbing the injected area. Two distinct periods of intense rubbing activity can be identified, a first phase occurring in the first 3 min and a second phase… CONTINUE READING
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