Evidence for a partially folded intermediate in alpha-synuclein fibril formation.

@article{Uversky2001EvidenceFA,
  title={Evidence for a partially folded intermediate in alpha-synuclein fibril formation.},
  author={Vladimir N. Uversky and Jie Li and Anthony L. Fink},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 14},
  pages={10737-44}
}
Intracellular proteinaceous aggregates (Lewy bodies and Lewy neurites) of alpha-synuclein are hallmarks of neurodegenerative diseases such as Parkinson's disease, dementia with Lewy bodies, and multiple systemic atrophy. However, the molecular mechanisms underlying alpha-synuclein aggregation into such filamentous inclusions remain unknown. An intriguing aspect of this problem is that alpha-synuclein is a natively unfolded protein, with little or no ordered structure under physiological… CONTINUE READING
Highly Influential
This paper has highly influenced 22 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 261 extracted citations

Similar Papers

Loading similar papers…