Evidence for a partially folded intermediate in alpha-synuclein fibril formation.

  title={Evidence for a partially folded intermediate in alpha-synuclein fibril formation.},
  author={Vladimir N. Uversky and Jie Li and Anthony L. Fink},
  journal={The Journal of biological chemistry},
  volume={276 14},
Intracellular proteinaceous aggregates (Lewy bodies and Lewy neurites) of alpha-synuclein are hallmarks of neurodegenerative diseases such as Parkinson's disease, dementia with Lewy bodies, and multiple systemic atrophy. However, the molecular mechanisms underlying alpha-synuclein aggregation into such filamentous inclusions remain unknown. An intriguing aspect of this problem is that alpha-synuclein is a natively unfolded protein, with little or no ordered structure under physiological… CONTINUE READING
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