Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model.

@article{Bnvlgyi2005EvidenceFA,
  title={Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model.},
  author={Agnes B{\'a}nv{\"o}lgyi and L{\'a}szl{\'o} P{\'a}link{\'a}s and T{\'i}mea Berki and Natalie Clark and Andrew Douglas Grant and Zsuzsanna Helyes and G{\'a}bor Pozsgai and J{\'a}nos Szolcs{\'a}nyi and Susan Diana Brain and Erika Pint{\'e}r},
  journal={Journal of neuroimmunology},
  year={2005},
  volume={169 1-2},
  pages={86-96}
}
The purpose of this study was to examine the involvement of the transient receptor potential vanilloid receptor 1 (TRPV1) in inflammatory processes observed in murine allergic contact dermatitis (ACD). Oxazolone-induced ACD evoked a significant ear swelling after 24-72 h. It was augmented in TRPV1 knockout mice at all time points and supported by histological analysis and measure of TNF-alpha. However, tissue swelling and cytokine generation was significantly reduced in both neurokinin 1… CONTINUE READING
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