Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland: leptin inhibits cortisol release directly.

@article{Bornstein1997EvidenceFA,
  title={Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland: leptin inhibits cortisol release directly.},
  author={Stefan R. Bornstein and K Uhlmann and A Haidan and Monika Ehrhart-Bornstein and Werner Alfred Scherbaum},
  journal={Diabetes},
  year={1997},
  volume={46 7},
  pages={1235-8}
}
The crucial role of glucocorticoids in obesity and insulin resistance and the actions of the OB protein leptin on the hypothalamic-pituitary-adrenal (HPA) axis suggest that there is an important interaction of leptin with the glucocorticoid system. Therefore, we designed a study to test the effect of leptin directly on adrenocortical steroidogenesis. Primary cultures of bovine adrenocortical cells were incubated with increasing concentrations (10-1,000 ng/ml) of recombinant mouse leptin for 24… CONTINUE READING

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