Evidence for a novel P2X purinoceptor in human placental chorionic surface arteries.

@article{Dobronyi1997EvidenceFA,
  title={Evidence for a novel P2X purinoceptor in human placental chorionic surface arteries.},
  author={I. Dobronyi and K. Hung and D. Satchell and M. Maguire},
  journal={European journal of pharmacology},
  year={1997},
  volume={320 1},
  pages={
          61-4
        }
}
To characterize the P2x purinoceptor of arteries of human term placenta, a non-innervated organ, actions of ATP, alpha, beta-methylene-ATP and UTP on de-endothelialized chorionic surface artery segments were compared. ATP and alpha,beta-methylene-ATP caused reversible concentration-dependent contractions, but UTP elicited little or no contraction up to 517 microM. Concentration-effect curves to ATP and alpha,beta-methylene-ATP were parallel, and alpha,beta-methylene-ATP, EC50 4.2 +/- 1.2 microM… Expand
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