Evidence for a novel P2X purinoceptor in human placental chorionic surface arteries.

  title={Evidence for a novel P2X purinoceptor in human placental chorionic surface arteries.},
  author={I. Dobronyi and K. Hung and D. Satchell and M. Maguire},
  journal={European journal of pharmacology},
  volume={320 1},
To characterize the P2x purinoceptor of arteries of human term placenta, a non-innervated organ, actions of ATP, alpha, beta-methylene-ATP and UTP on de-endothelialized chorionic surface artery segments were compared. ATP and alpha,beta-methylene-ATP caused reversible concentration-dependent contractions, but UTP elicited little or no contraction up to 517 microM. Concentration-effect curves to ATP and alpha,beta-methylene-ATP were parallel, and alpha,beta-methylene-ATP, EC50 4.2 +/- 1.2 microM… Expand
Characterization of P2 receptors for purine and pyrimidine nucleotides in human placental cotyledons
Regional variation in P2 receptor expression in the rat pulmonary arterial circulation
Co-localization of P2Y1 receptor and NTPDase1/CD39 within caveolae in human placenta.
P2 Receptors in Blood Vessels
Nucleotide-evoked relaxation of human coronary artery.
Purinergic Signaling and Blood Vessels in Health and Disease
Cardiovascular Biology of Purines


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