Evidence for a multifactorial process involved in the impaired flow response to nitric oxide in hypertensive patients with endothelial dysfunction.

@article{Kelm1996EvidenceFA,
  title={Evidence for a multifactorial process involved in the impaired flow response to nitric oxide in hypertensive patients with endothelial dysfunction.},
  author={Malte Kelm and Michael Preik and David J. Hafner and Bodo Eckehard Strauer},
  journal={Hypertension},
  year={1996},
  volume={27 3 Pt 1},
  pages={
          346-53
        }
}
The assessment of endothelial function in hypertensive patients receiving acetylcholine has revealed conflicting results. Whether an impaired flow response to acetylcholine is explained solely by a diminished endothelial synthesis of nitric oxide (NO) remains unclear as yet. In the present study, we tested the hypothesis that mechanisms other than reduced NO synthesis contribute to the hypertension-associated impairment of endothelium-dependent vasodilation. Therefore, the dilatory response to… CONTINUE READING
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