Evidence for a missed signal to the CD8+ cells in CSF of Multiple Sclerosis patients

@article{Saresella2005EvidenceFA,
  title={Evidence for a missed signal to the CD8+ cells in CSF of Multiple Sclerosis patients},
  author={Marina Saresella and A. Grope and Livianna Speciale and Roberta Mancuso and R. Benedictis and Domenico Caputo and Pasquale Ferrante},
  journal={The Italian Journal of Neurological Sciences},
  year={2005},
  volume={16},
  pages={479-485}
}
Peripheral blood (PB) and cerebrospinal fluid (CSF) lymphocyte subpopulations, defined by various T-cell specific monoclonal antibodies and flow cytometry, were analysed in 44 relapsing remitting multiple sclerosis (RRMS) patients (including 21 subjects in the acute phase and 23 in the stable phase), 40 chronic-progressive multiple sclerosis (CPMS) patients, and 24 patients with other neurological diseases (OND), in order to verify the presence of any abnormality in the lymphocyte subset… 
2 Citations
High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay.
TLDR
It is found that both CD4(+) and CD8(+) T cells targeted against several CNS autoantigens were widely prevalent in patients with MS and healthy individuals and both subsets should be a consideration in the development of novel therapeutic strategies.

References

SHOWING 1-10 OF 47 REFERENCES
T-cell phenotypic profiles in the cerebrospinal fluid and peripheral blood of multiple sclerosis patients
The imbalance in CSF T cell subsets in active multiple sclerosis
TLDR
Evaluation of the percentages of CD4+ and CD8+ cells in CSF by flow cytometry could be a useful indicator of disease activity in MS.
Decrease of suppressor inducer (cd4+ 2h4+) t cells in multiple sclerosis cerebrospinal fluid
TLDR
The results indicate that the CD4+ T cells in the cerebrospinal fluid of patients with multiple sclerosis are predominantly helper inducer, as opposed to suppressor inducer T cells, and that the relative decrease of suppressors in the peripheral blood of multiple sclerosis patients is not due to their migration to the CerebrospINAL fluid.
Monoclonal antibody-defined immunoregulatory cells in multiple sclerosis cerebrospinal fluid.
TLDR
Repeat studies of three patients showed that perturbations of CSF suppressor/cytotoxic cells were dependent on clinical status, adding to the accumulating data that suggest altered immunity in the pathogenesis of MS.
Cellular immunoregulatory mechanisms in the central nervous system: Characterization of noninflammatory and inflammatory cerebrospinal fluid lymphocytes
TLDR
Findings indicate that the CNS is routinely surveyed by particular subsets of lymphocytes different from those in the blood, and cellular immune reaction in the CNS varies according to the types of CNS inflammatory conditions.
Selective loss of a subset of T helper cells in active multiple sclerosis.
TLDR
Two-color analysis of T-cell subsets may be a more sensitive indicator than conventional single-marker assays of abnormal immune status in MS patients, and is compared with healthy age-matched controls and in patients with other neurologic diseases.
Suppressor T‐lymphocytes in multiple sclerosis: Analysis of patients with acute relapsing and chronic progressive disease
TLDR
It is suggested that modulation (a spontaneous or induced variability in the expression) of individual cell surface antigens may explain the differences seen between this study and other reported series.
Loss of suppressor T cells in active multiple sclerosis. Analysis with monoclonal antibodies.
TLDR
There is loss of peripheral suppressor cells in many patients with active MS, suggesting that immunoregulatory abnormalities contribute to the pathogenesis of the disease.
Selective loss of the suppressor-inducer T-cell subset in progressive multiple sclerosis. Analysis with anti-2H4 monoclonal antibody.
TLDR
The results suggest that in progressive multiple sclerosis decreases in inducers of suppressor T cells may permit the activation of cells reactive with elements of the central nervous system.
Suppressor cell function in multiple sclerosis: Correlation with clinical disease activity
Concanavalin A (Con A)–activated suppressor cell activity was determined in multiple sclerosis (MS) patients who had been assigned to one of three subgroups, those with active disease, those
...
...