Evidence for a major gene underlying bone size variation in the Chinese.

@article{Liu2004EvidenceFA,
  title={Evidence for a major gene underlying bone size variation in the Chinese.},
  author={Peng-yuan Liu and Yue-Juan Qin and Robert Roy Recker and Hong-Wen Deng},
  journal={American journal of human biology : the official journal of the Human Biology Council},
  year={2004},
  volume={16 1},
  pages={68-77}
}
Osteoporosis is a major public health problem defined as a loss of bone strength, of which bone size is an important determinant. In the present study, familial correlation and segregation analyses for the spine and hip bone sizes were performed for the first time in a Chinese sample composed of 393 nuclear families with a total of 1,193 individuals. The results indicate a major gene of codominant inheritance for spine bone size; however, there is no evidence of a major gene influencing hip… CONTINUE READING

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