Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses.

@article{Rothkamm2003EvidenceFA,
  title={Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses.},
  author={Kai Rothkamm and Markus L{\"o}brich},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 9},
  pages={5057-62}
}
DNA double-strand breaks (DSBs) are generally accepted to be the most biologically significant lesion by which ionizing radiation causes cancer and hereditary disease. However, no information on the induction and processing of DSBs after physiologically relevant radiation doses is available. Many of the methods used to measure DSB repair inadvertently introduce this form of damage as part of the methodology, and hence are limited in their sensitivity. Here we present evidence that foci of gamma… CONTINUE READING
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