Evidence for a gender-specific protective role of innate immune receptors in a model of perinatal brain injury.

@article{PimentelCoelho2013EvidenceFA,
  title={Evidence for a gender-specific protective role of innate immune receptors in a model of perinatal brain injury.},
  author={Pedro Moreno Pimentel-Coelho and Jean-Philippe Michaud and Serge Rivest},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 28},
  pages={
          11556-72
        }
}
Hypoxia-ischemia is a common cause of neurological impairments in newborns, but little is known about how neuroinflammation contributes to the long-term outcome after a perinatal brain injury. In this study, we investigated the role of the fractalkine receptor chemokine CX3C motif receptor 1 (CX3CR1) and of toll-like receptor (TLR) signaling after a neonatal hypoxic-ischemic brain injury. Mice deficient in the TLR adaptor proteins Toll/interleukin-1 receptor-domain-containing adaptor protein… CONTINUE READING
Highly Cited
This paper has 22 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 81 references

Rat model of perinatal hypoxic-ischemic brain damage.

Journal of neuroscience research • 1999
View 5 Excerpts
Highly Influenced

The HMGB1 receptor RAGE mediates ischemic brain damage.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2008
View 4 Excerpts
Highly Influenced

Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia.

Proceedings of the National Academy of Sciences of the United States of America • 1998
View 6 Excerpts
Highly Influenced

Expression of Toll-Like Receptors in the Developing Brain

PloS one • 2012
View 6 Excerpts
Highly Influenced

Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2008
View 5 Excerpts
Highly Influenced

HMGB1, a novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2006
View 4 Excerpts
Highly Influenced