Evidence for a functional receptor for cyclosporin A on the surface of lymphocytes.

Abstract

Cyclosporin A (CsA) is an immunosuppressive agent that inhibits the synthesis of lymphokines by T lymphocytes at the level of transcription. A cytoplasmic protein, cyclophilin, is the most thoroughly studied CsA-binding protein, but its ubiquitous presence in cells of all types raises questions about its role in immunosuppression. In an attempt to ascertain… (More)

Topics

Cite this paper

@article{Cacalano1992EvidenceFA, title={Evidence for a functional receptor for cyclosporin A on the surface of lymphocytes.}, author={Nicholas A. Cacalano and B. X. Chen and W. Louis Cleveland and B. F. Erlanger}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1992}, volume={89 10}, pages={4353-7} }