Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis.

Abstract

Aseptic loosening is a major complication of prosthetic joint surgery and is manifested as chronic inflammation, pain, and osteolysis at the bone implant interface. The osteolysis is believed to be driven by a host inflammatory response to wear debris generated from the implant. In our current study, we use a selective inhibitor (celecoxib) of cyclo… (More)

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