Evidence for a direct action of acetylcholine on the gastric oxyntic cell of the amphibian.

@article{Ruiz1984EvidenceFA,
  title={Evidence for a direct action of acetylcholine on the gastric oxyntic cell of the amphibian.},
  author={Marie Christine Ruiz and Fab{\'i}an Michelangeli},
  journal={The American journal of physiology},
  year={1984},
  volume={246 1 Pt 1},
  pages={G16-25}
}
The possibility of a direct action of acetylcholine (ACh) on the oxyntic cell not mediated by histamine release was studied in resting isolated gastric mucosae. H+ secretion and histamine release, and their relationship, were studied under ACh stimulation and other conditions. ACh released histamine from mucosal stores and stimulated H+ secretion. H2-receptor blocker cimetidine largely inhibited ACh-induced stimulation of H+ transport but not histamine release. Atropine inhibited the… CONTINUE READING