Evidence for a conserved role of retinoic acid in urodele amphibian meiosis onset.

@article{Wallacides2009EvidenceFA,
  title={Evidence for a conserved role of retinoic acid in urodele amphibian meiosis onset.},
  author={Angelina Wallacides and Amand Chesnel and Dominique Chardard and St{\'e}phane Flament and H{\'e}l{\`e}ne Dumond},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2009},
  volume={238 6},
  pages={1389-98}
}
Pleurodeles waltl is a urodele amphibian displaying a ZZ/ZW genetic mode of sex determination. Gonad differentiation can later be modulated by hormone treatment. To investigate germ cell differentiation, we analyzed the expression of the meiosis marker PwDmc1 and show that germ cells enter meiosis in late larval life in females, and 2 months after metamorphosis in males. Organotypic cultures of gonad-mesonephros complexes demonstrated that retinoic acid triggers meiosis entry in P. waltl. In… CONTINUE READING
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