Evidence for a concerted reaction between lipid hydroperoxides and polypeptides.

  title={Evidence for a concerted reaction between lipid hydroperoxides and polypeptides.},
  author={Joachim Fruebis and Sampath Parthasarathy and Daniel Steinberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={89 22},
The events accompanying oxidative modification of low density lipoprotein (LDL) are multiple and complex, and the precise mechanisms remain to be determined. In the present studies, we examined a simple system in which we first prepared large amounts of lipid hydroperoxides (from linoleic acid or from phospholipids containing linoleic acid) by using soybean lipoxygenase (linoleate:oxygen oxidoreductase, EC Linoleoyl hydroperoxide was then incubated with polypeptides in the absence… CONTINUE READING


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