Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS.

@article{Gianfrancesco2017EvidenceFA,
  title={Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS.},
  author={Milena A Gianfrancesco and Pernilla Stridh and Brooke L. Rhead and Xiaorong Shao and Edison Xu and Jennifer Graves and Tanuja Chitnis and Amy T Waldman and Timothy Lotze and Teri L. Schreiner and Anita L. Belman and Benjamin M. Greenberg and Bianca Weinstock-Guttman and Gregory Aaen and Jan Mendelt Tillema and Janace Hart and Stacy J. Caillier and Jayne M. Ness and Yolanda Harris and Jennifer P. Rubin and Meghan S Candee and Lauren B. Krupp and Mark P. Gorman and Leslie A. Benson and Moses Rodriguez and Soe Soe Mar and Ilana Kahn and John W. Rose and Shelly Roalstad and Theron Charles Casper and Ling Shen and Hong L. Quach and Diana Quach and Jan Hillert and Maria B{\"a}{\"a}rnhielm and Anna Hedstrom and Peter Sundstr{\"o}m and Ingrid Kockum and Lars Alfredsson and Catherine Metayer and Catherine Schaefer and Lisa F Barcellos and Emmanuelle Waubant},
  journal={Neurology},
  year={2017},
  volume={88 17},
  pages={
          1623-1629
        }
}
OBJECTIVE To utilize Mendelian randomization to estimate the causal association between low serum vitamin D concentrations, increased body mass index (BMI), and pediatric-onset multiple sclerosis (MS) using genetic risk scores (GRS). METHODS We constructed an instrumental variable for vitamin D (vitD GRS) by computing a GRS for 3 genetic variants associated with levels of 25(OH)D in serum using the estimated effect of each risk variant. A BMI GRS was also created that incorporates the… CONTINUE READING

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