Evidence for a cancer-specific switch at the CDK4 promoter with loss of control by both USF and c-Myc

@article{Pawar2004EvidenceFA,
  title={Evidence for a cancer-specific switch at the CDK4 promoter with loss of control by both USF and c-Myc},
  author={Snehalata A Pawar and Marilyn N. Szentirmay and Heiko Hermeking and Mich{\`e}le Sawadogo},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={6125-6135}
}
USF and c-Myc are basic helix–loop–helix transcription factors with similar DNA-binding specificities, but antagonistic effects on cellular transformation. In order to determine how these opposite functions correlate with the transcriptional activities of the two factors on particular downstream targets, we investigated the roles of USF and c-Myc in expression of CDK4, a known direct target of c-Myc. Overexpression of either c-Myc or USF2, but not USF1, stimulated the expression of CDK4… CONTINUE READING

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