Evidence for a Type 1 diabetes-specific mechanism for the insulin gene-associated IDDM2 locus rather than a general influence on autoimmunity.

@article{Tait2004EvidenceFA,
  title={Evidence for a Type 1 diabetes-specific mechanism for the insulin gene-associated IDDM2 locus rather than a general influence on autoimmunity.},
  author={Karen F Tait and Joanne E Collins and Joanne M. Heward and Iain A. Eaves and Hywel Snook and Jayne A. Franklyn and Anthony Barnett and J. A. Todd and Mel J. Maranian and Alastair D Compston and Stephen J Sawcer and Stephen C. L. Gough},
  journal={Diabetic medicine : a journal of the British Diabetic Association},
  year={2004},
  volume={21 3},
  pages={267-70}
}
AIMS The Type 1 diabetes susceptibility locus, IDDM2, has been mapped to a variable number of tandem repeats (VNTR) region 5' upstream of the insulin (INS) and insulin-like growth factor (IGF2) genes on chromosome 11p15. The function of the VNTR is uncertain; however, it may influence the thymic expression of the insulin gene and affect the development of immune self-tolerance. The aim of this study was to investigate whether the INS VNTR region is a Type 1 diabetes-specific locus or acting as… CONTINUE READING