Evidence for a Mediator of RNA Polymerase II Transcriptional Regulation Conserved from Yeast to Man

@article{Boube2002EvidenceFA,
  title={Evidence for a Mediator of RNA Polymerase II Transcriptional Regulation Conserved from Yeast to Man},
  author={Muriel Boube and Laurent Joulia and David L. Cribbs and Henri-Marc Bourbon},
  journal={Cell},
  year={2002},
  volume={110},
  pages={143-151}
}
Mediator complexes (MED) link transcriptional regulators to RNA polymerase II. Here, we summarize the latest advances on the functional organization of yeast Mediator. We argue for the existence of a "universal" Mediator structurally conserved from yeast to man, based on an extensive analysis of sequence databases. Finally, we examine the implications of these observations for the physiological roles of metazoan MED subunits. 

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 95 extracted citations

Recovery of Yeast Saccharomyces cerevisiae after Thermal Insult

A L Hänninen, Docent Sirkka Keränen, Docent Matti Korhola
2010
View 5 Excerpts
Highly Influenced

Structure of the Mediator subunit Cyclin C and subunit interaction studies within the Mediator head module

Sabine Hoeppner, Patrick Cramer betreut, Ehrenwörtliche Versicherung
2005
View 6 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 52 references

A comprehensive two-hybrid analysis to explore the yeast protein interactome.

Proceedings of the National Academy of Sciences of the United States of America • 2001
View 7 Excerpts
Highly Influenced

The structural and functional organization of the yeast mediator complex.

The Journal of biological chemistry • 2001
View 16 Excerpts
Highly Influenced

Transcriptional regulation machinery: structure illuminates function

S. Malik, R. G. Roeder
Cell • 2000
View 5 Excerpts
Highly Influenced

Mediator protein mutations that selectively abolish activated transcription.

Proceedings of the National Academy of Sciences of the United States of America • 1999
View 16 Excerpts
Highly Influenced

Srb10 and Kin28 cyclin-dependent kinases

F. J. Asturias, Y. W. Jiang, +7 authors R. D. berg
Mol. Cell 2, • 1999
View 7 Excerpts
Highly Influenced

The yeast Mediaprotein interactome

J. S. Kang, S. H. Kim, +6 authors H. M. Y. J. Bourbon
Proc . Natl . Acad . Sci . USA Mol . Cells • 2001
View 6 Excerpts
Highly Influenced

Transcription control by E 1 A and MAP kinase pathway

G. T. Cantin, G. Wang, A. Shevchenko, J. A.
2002

Similar Papers

Loading similar papers…